We are a research group in the BioMedical Engineering Department, Institute of advanced clinical medicine and International Cancer Institute at Peking University. Our lab is primarily a computational biology/bioinformatic group with both ‘wet’ and ‘dry’ labs that develop and use a wide range of genomic and epigenomic sequencing technologies along with bioinformatic methods to explore biomedical questions. Our aim is to explore and understand transcriptomic and epigenetic regulation in both normal and abnormal cells in varied life process. Despite of almost the same copies of genome, cells from different tissues, developmental stages or healthy status display varied functions and phenotypes mainly due to differential gene transcription, in which chromatin and epigenetic regulation plays key roles. Therefore, We are focusing on (but not restricted to) studying how cell fates are controlled by chromatin and epigenome in human health and disorders to provide novel therapy directions to fight against diseases.
Our lab currently focus on the following directions:
We are looking for passionate new PhD students, Postdocs, and Research Assistants to join the team (more info) !
We are grateful for funding from NSFC and MOST.
We work closely with many collaborators, including collaborators in Peking University, Army Medical University, and collaborators from hospitals.
23 March 2025
Our paper describing SC-VAR is published in Briefings in Bioinformatics today, Congrats Gefei!
1 March. 2025
Our paper about acral melanoma is now published online in Theranostics! doi:10.7150/thno.99526 Congrats Tian Jie!
5 Feb. 2025
Our paper about acral melanoma is now accepted into Theranostics!
20 December 2024
New paper published in Advanced Science!
1 September 2024
Xuemei Tian join the lab as a PhD student. Welcome!
25. June 2024
Jei Tian passed a doctoral thesis defence. Congrats!
4. September 2023
Welcome new lab members, Dongchen He and Tong Liu!
22. March 2023
The Lai Lab website at github is now open. Welcome!